Page 108 - Malaysian Journal of Health Promotion, Vol 4 (Supplementary 1) 2022

Malaysian Journal of Health Promotion, Vol 4 (Supplementary 1) 2022
th
14 MOH-AMM Scientific Meeting 2022 in conjunction with 23 NIH Scientific Conference Abstract Book
rd
ID 121 OPTIMIZATION OF BAYESIAN PENALIZED LIKELIHOOD (BPL) Β PENALIZATION
FACTORS VALUE FOR PET/CT F18-FDG IMAGING

2 1
2
1
Mohamad Aminudin Said , Abdulkadhim Saadoon ,Faizal K.P. Kunchi Mohamed Institut Kanser Negara
2 Universiti Kebangsaan Malaysia

INTRODUCTION: Positron Emitter Tomography (PET) is routinely reported for the lesion
uptake as a part of the image interpretation and reporting. The use of PET quantification for
diagnosis is not widely accepted due to its inconsistency due to large number of potential
sources of bias and variance, including data processing and patient status. This study aims to
define the optimal β penalization factors for a minimum tumor uptake, modeled by a NEMA
PET IQ phantom to improved SUV estimation
METHODS: NEMA phantom was prepared to simulate PET/CT whole-body scan (WBS) with
tumor background ratio 2.5:1. Quadratic dose protocol for the WBS was adopted and the
minimal scan time (Tmin) was defined at COV=15% as recommended by the EANM. β
penalization factors, in the range of 100 to 1000 were examined on the reconstructed image
corrected for partial volume effect. To define the optimal β penalization factors, the tolerance
between the calculated and actual activity was calculated and the effective dose between
different activity formulations was assessed.
RESULTS: Tmin for the 100 to 1000 β penalization factors was in the range of 55 to 580
seconds. For the logarithmic and polynomial fitted functions, the highest overall accuracy was
obtained using β penalization factors of 600 and 300 each. Analysis of the patient-specific
18F-FDG dose shows that administered activity reduces as the β penalization factors increases.
DISCUSSION/CONCLUSION: In this study, we suggested β600 as the best option for the
routine 18F-FDG clinical PET/CT due to the higher accuracy and faster acquisition time
(Tmin=97 seconds).

ID 122 SOMETHING SINISTER CAN LURK BEHIND THE INVISIBLE AND BE PAIN-FREE

1,2
1,2
Nandinii Ramasenderan & Ahmad Sukari Halim
1 Reconstructive Sciences Unit, School of Medical Sciences, Universiti Sains Malaysia
2 Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia

INTRODUCTION: Skin cancer is among the top 10 cancers in Malaysia. Melanoma is the
deadliest of all skin malignancies. Acral lentiginous melanoma, are known for their debilitating
effect due to their hidden location.
CASE REPORT: Madam SR, 75-years old Malaysian woman, appeared with a three-year-old
skin lesion on her right heel. Prior to seeking treatment, it had grown during the last six
months. There was no history of trauma, no family history of skin cancer, and no signs or
symptoms of constitutional illness. Her skin lesion was 5cm x 5cm in size, with uneven borders
and hyperpigmented tone. Acral lentiginous melanoma was discovered through wedge
biopsy. Following that, she had a wide local excision, medial plantar flap and split thickness
skin graft.
DISCUSSION: Amputation is no longer the surgical option for large skin tumors, particularly
those on the foot. We raised a medial plantar flap from the instep area of the foot to the
defect. A skin graft was used to cover the donor site. The flap developed congestion within
the first 24-hours and was explored: flap returned to the original site, hematoma evacuated,

82