Page 59 - Malaysian Journal of Health Promotion, Vol 4 (Supplementary 1) 2022

Malaysian Journal of Health Promotion, Vol 4 (Supplementary 1) 2022
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14 MOH-AMM Scientific Meeting 2022 in conjunction with 23 NIH Scientific Conference Abstract Book
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METHODS: This study was a cross-sectional, population-based survey that employed a two-
stage stratified random sampling design using data from the National Health and Morbidity
Survey (NHMS) 2019. A total of 3,816 adults, aged 18 years and above participated in this
survey; majority aged between 31 to 59 years. Complex sampling analysis was used to
determine the prevalence and associated factors among adults of normal BMI with central
obesity.
RESULTS: The findings showed that adults of normal BMI with central obesity was 12.3% in
men and 35.1% in women. Significant association were found in two NCDs (male p<0.001,
female p=0.004), three NCDs (p=0.005 in men; p=0.001 in women), adults aged 31-59 years
(p<0.001 for both gender), 60 years and above (p<0.001 for both genders), female secondary
education (p=0.024), male current smoker (p=0.039) and inactive males (p=0.046).
DISCUSSION/CONCLUSION: Normal BMI with central obesity was associated with NCDs such
as hypertension, hypercholesterolemia, and diabetes. The present findings show importance
of screening those adults who have normal BMI with central obesity among middle-aged
adults. Future studies on dietary intervention should be carried out to reduce the burden of
disease for this population.

ID 33 ANALYSIS OF AGREEMENT AND VALIDATION OF A1CNOW+ IN HBA1C MEASUREMENT

Mohd Ruhaizie Riyadzi, Nur Liana Ab Majid, Wan Shakira Rodzlan Hasani, Halizah Mat Rifin, Hamizatul Akmal
Abd Hamid, Thamil Arasu Saminathan, Tania Gayle Robert Lourdes, Hasimah Ismail and Muhammad Fadhli
Mohd Yusoff.
Institute for Public Health, National Institutes of Health, Ministry of Health Malaysia

INTRODUCTION: The objective of this study is to analysed the agreement and validation of
glycated haemoglobin (HbA1c) measurement between A1CNow+ and laboratory result.
METHODS: In this cross-sectional study, proportionate quota sampling was applied.
Respondents (n = 393) were those aged ≥18 years old, not known to have diabetes or
previously diagnosed with diabetes but have never been on the treatment for the disease.
2ml of venous blood was withdrawn from each respondent. 5μl were tested in-situ using
A1CNow+ (VPOCT) and the balanced kept in the EDTA tube and sent to laboratory (LAB) for
analysis using Bio-RAD D10. Another 5μl of capillary blood taken from the same participant
for in-situ measurement (CPOCT). Intraclass correlation coefficient (ICC) was applied in the
analysis of agreement. The accuracy, sensitivity, specificity, and both positive/negative
predictive values (PPV/NPV) were analysed using two HbA1c cut-offs: 6.3% and 6.5%. These
analyses were done using RStudio by comparing LAB vs CPOCT (LC) and LAB vs VPOCT (LV).
RESULTS: The ICC is 0.93, 95%CI: 0.91-0.945 (LC) and 0.90, 95%CI: 0.663 - 0.954 (LV). Using
6.3% cut-off, the accuracy, sensitivity, specificity, PPV and NPV were 93.9%, 85.5%, 95.3%,
74.6% and 97.6% (LC), and 94.1%, 95.5%, 94.0%, 66.7% and 99.4% (LV) respectively, and
96.2%, 93.5%, 96.5%, 78.2% and 99.1% (LC) and 95.4%, 100.0%, 94.9%, 67.3%, 100.0% (LV)
respectively when using 6.5% cut-off.
DISCUSSION/CONCLUSION: The POCT using A1CNow+ shows excellent agreement, as well as
having good accuracy, specificity and sensitivity (>85.0%) at both 6.3% and 6.5% HbA1c cut-
off when compared with laboratory result.

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