Page 50 - Malaysian Journal of Health Promotion, Vol 4 (Supplementary 1) 2022

Malaysian Journal of Health Promotion, Vol 4 (Supplementary 1) 2022
14 MOH-AMM Scientific Meeting 2022 in conjunction with 23 NIH Scientific Conference Abstract Book
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publications, collaboration for publication, publications by type, journal preferences for the
publication, and citation of the scientific articles.

RESULTS: The results of the study indicated that Dr. Lee is a prolific writer in the field of
Medical Entomology. Throughout his career and available records until 31 December 2021,
he has contributed 998 scientific items, including 338 articles, 502 presentations and 158
technical papers and guidelines. Research work conducted by Dr. Lee has been well accepted
in developed (e.g. the United Kingdom) and developing (e.g. Thailand) countries. He used the
English language to disseminate the majority of his research work and findings.
DISCUSSION/CONCLUSION: Dr Lee believes in teamwork in which 90% of his research work
was the outcome of collaboration. His publication is of good quality in which 1,963 documents
have cited his works, contributing to a high H-index of 27 as a recognition of his excellent
works. This study examined the trend of scientific publications produced by a scientist
throughout the course of his research career, in order to serve as a role model for the junior
researchers.

ID 17 IN VITRO α-GLUCOSIDASE AND DPP-IV INHIBITORY ACTIVITIES BY RESISTANT STARCH
TYPE 2 AND 4

1
1
2
1*
2*
Ezarul Faradianna Lokman , Sal Hazreen Bugam , Aina Shafiza Ibrahim , Nurleyna Yunus , Fazliana Mansor ,
3*
Vimala Balasubramaniam & Awang Zulfikar Rizal Awang Seruji 2
1 Endocrine and Metabolic Unit, Nutrition, Metabolism and Cardiovascular Research Centre (NMCRC), Institute

for Medical Research, National Institutes of Health Complex, Ministry of Health Malaysia
2 Downstream Technology Division, CRAUN Research Sdn. Bhd.
3 Nutrition Unit, Nutrition, Metabolism and Cardiovascular Research Centre (NMCRC), Institute for Medical
Research, National Institutes of Health Complex, Ministry of Health Malaysia

INTRODUCTION: The beneficial effects of resistant starch (RS) consumption on health in
terms of reducing postprandial hyperglycaemia are evident. Our previous study showed that
the blood glucose area under the curve of RS-treated groups was decreased in spontaneously
type 2 diabetes (T2D) Goto kakizaki rat. However, the mechanisms involved have not been
explored. In this study, we identified Dipeptidyl peptidase (DPP)-IV and α-glucosidase
inhibitors activities, two classes of oral drugs used to treat T2D by decreasing the postprandial
hyperglycemia via digestive system.
METHODS: The inhibitory activities of α-Glucosidase and DPP-IV in response to the Sarawak
sago RS2 and RS4 were tested at different concentrations (0.1, 1 and 10 mg/ml) and
compared with positive control.
RESULTS: RS2 at 1 and 10 mg/ml inhibited DPP-IV activity by 87.72 ± 9.7 and 82.27 ± 5.1%.
RS4 only showed DPP-IV inhibitory activity at 10 mg/ml by 87.07 ± 8.9%. For α-glucosidase
inhibitor, at 10 mg/ml, RS2 and RS4 exhibited highest α-glucosidase inhibitory activity at 93,
95 and 97% respectively.
DISCUSSION/CONCLUSION: The glucose lowering effect by RS mainly involve the digestive
system via the DPP-IV and α-Glucosidase inhibitory activities by delaying the process of
carbohydrates hydrolysis and glucose absorption. In conclusion, Sago RS2 and RS4 might have
potential roles in regulating glucose via α- Glucosidase and DPP-IV inhibitory activities which
leads to reduced glucose absorption in the intestine.

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