Page 27 - Care-for-vulnerable-populations-during-COVID-19-pandemic

Severe liver failures/injuries with SARS-CoV-2

infection

Severe liver failures and injuries with SARs-CoV-2 infection. It was also reported one case
where a 65-year-old male with positive throat swab on admission with mildly elevated ALT,
mild hepatitis. He developed from mild to moderate ARDS where oxygen therapy was required.
He was given some vasopressor, and antiviral Kaletra and interferon IFN β. His ECHO was
normal and ultrasound was also normal. His ALT increased to 400 and subsequent to that, there
were increased in INR, total bilirubin. His MELD score was increased to about 40. Eventually,
he passed away.
In another case of a 59-year-old, well-controlled patient with RVD disease. This patient has
severe hepatitis with AST>1200 u/l, ALT~700 u/l. He was negative for other hepatotropic
viruses: HAV, HBV, HCV, HEV, CMV, EBV, and also autoimmune markers. Luckily this
patient survived and he was discharged.