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Research paper: Manifestations and prognosis of
gastrointestinal and liver involvement in patients with
COVID-19: a systematic review and meta-analysis
(Lancet Gastroenterol Hepato 2020 Published Online 12 May 2020)
The meta-analysis based on 12 studies show that the pooled prevalence of liver injury in
COVID-19 is 19%, increased AST is 21%, increased ALT somewhat lower than AST at 18%,
prevalence of increased total bilirubin of 6% and prevalence of decreased albumin at 6%. The
meta-analysis also showed deranged liver biochemistry is associated with more severe COVID-
19 cases.
