Page 41 - COVID-19-Mortality-review-in-Malaysia-and-updates-on-clinical-management-of-COVID-19

MOH Guidelines

Based on the MOH guidelines, for category 4 and 5, we use:
Lopinavir-Ritonavir 2tabs BD OR Atazanavir 300mg daily and Ritonavir 100mg daily
AND
Favipiravir 1600mg BD for 1 day then 600mg BD (teratogenic).
If < 7 days of illness:
● SC interferons Beta 1a 44mcgm stat then EOD OR
● Interferon Beta 1b 250mcg stat then EOD (3-5 doses)

We have to remember that favipiravir is teratogenic, and we have to be careful in
the reproductive age group.

If <7 days of illness, data from Hong Kong showed that they were using interferon
beta therapy and if > 7 days, they use these two drugs. These are the drugs which are

part of our registry. We will analyze the data the same way as we have analyzed the
data with hydroxychloroquine from time to time and revise our guidelines.

We still don't know whether category 3 with risk factors or category 3 with warning
signs; should we start treatment? Category 4 and 5 are clear in terms of treatment.