Page 37 - COVID-19-Mortality-review-in-Malaysia-and-updates-on-clinical-management-of-COVID-19
P. 37
Retrospective Analysis of Hydroxychloroquine in 84
Hospitalized Patients With COVID-19: Study Arm
There are many studies on hydroxychloroquine. I just want to put up one study, the
French study that said that “hydroxychloroquine is a wonder drug and nobody should
live without the drug”. It is actually a retrospective cohort study where they looked at
all their patients who were on hydroxychloroquine versus those who are not on
hydroxychloroquine [9]. They tried to balance all the relevant confounding factors like
age, gender, comorbidities, BMI>30kg/m , 3rd trimester of pregnancy, treatment with
2
angiotensin-converting enzyme (ACE) inhibitor or an angiotensin receptor blocker
(ARB), times since symptom onset and severity of disease. These are all the important
parameters which they have adjusted for.
Diagram 19: Baseline characteristics of patients in the hydroxychloroquine study
by Mahévas et al.
Hydroxychloroquine was given to patients who were around Day 8 of illness. Many
of them actually require oxygen, SpO2 of 92%.