Page 87 - Malaysian Journal of Health Promotion, Vol 4 (Supplementary 1) 2022

Malaysian Journal of Health Promotion, Vol 4 (Supplementary 1) 2022
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14 MOH-AMM Scientific Meeting 2022 in conjunction with 23 NIH Scientific Conference Abstract Book
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4 Kuala Lumpur Hospital, Ministry of Health Malaysia
5 Pulau Pinang Hospital, Ministry of Health Malaysia
6 Clinical Research Centre, Penang, Ministry of Health Malaysia
7 Selayang Hospital, Ministry of Health Malaysia
8 Tengku Ampuan Rahimah Hospital, Klang, Ministry of Health Malaysia
9 Institute for Medical Research, Ministry of Health Malaysia

INTRODUCTION: Glomerular filtration rate (GFR) and albuminuria are widely accepted as two
important aspects of kidney function; their assessment is essential for clinical practice,
research and public health. We aim to determine the prevalence of deranged estimated
glomerular filtration (eGFR) and albuminuria among adults in Malaysia.
METHODS: A nationwide, population-based, cross-sectional study was conducted in 2018
among adults aged ≥18-year-old in Malaysia. A total of 1,398 adults were randomly selected,
using the stratified cluster method. The estimated glomerular filtration rate (eGFR) was
measured with a calibrated serum creatinine using the CKD-EPI equation. Albuminuria was
defined as a urine albumin-creatinine ratio of ≥ 30mg/g.
RESULTS: The final analysis set comprised 890 respondents. A total of 42.0% of respondents
had deranged eGFR of ≤ 90 ml/min/1.73m2, nearly double the prevalence compared to a
similar study in 2011 (21.9%). Further breakdown showed that 35.2% (95%CI: 30.30, 40.44)
had mildly decreased renal function (eGFR of 60–89 ml/min/1.73m2) and 6.8% (95% CI: 4.71,
9.76) had moderate to severe renal failure (eGFR < 60 ml/min/1.73m2). Albuminuria was
detected in 16.9% of the sample. Albuminuria was three times higher in the diabetic group
(37.3%) compared to the non-diabetic group (11.4%).
DISCUSSION/CONCLUSION: High albuminuria and low eGFR are independent risk factors for
cardiovascular and renal events. In light of this finding, more effort is required to ensure
health care providers adhere strictly to clinical practice guidelines, which recommend regular
screening for eGFR and albuminuria, especially among diabetic patients.

ID 81 HOW IS PHYSICAL ACTIVITY RELATED WITH THE DEVELOPMENT OF S-ANTIBODY FOR
COVID-19 VACCINATION

Noor Aliza Lodz, Mohd Hatta bin Abdul Mutalip, Nurdiyana Farhana binti Mat Tamizi, Chong Zhuo Lin
Institute for Public Health, Ministry of Health, Setia Alam

INTRODUCTION: COVID-19 vaccination provides vaccine recipients protection against SAR-
CoV-2 infection in varying degree. There are many factors that distribute to better immune
response. The purpose of this study is to determine the effect of physical activity on spike
protein (S-antibody) development among Covid-19 vaccinees.
METHOD: 2,513 respondents were recruited in this prospective cohort study. The
respondents had come for five follow-up visits which were the baseline, second dose
vaccination, two weeks after completed dose, three months and six months after vaccination.
During the baseline, respondents were asked about their physical activities using the
International Physical Activity Questionnaires (IPAQ) tool. There were 4 domains asked in the
tool, but the respondents were divided into two categories at the end; active and inactive.
The dependent variable was Covid-19 S-antibody development. The mean difference of the
S-antibody titre for each group were tested using Independent t-test in every visits.
RESULTS: As expected, the titre of spike protein antibody for both groups increased after
vaccination despite of their physical activity level. During the second visit, the S-antibody

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