Page 22 - NIH Bulletin Vol. 16 December 2020

Bulletin National Institutes of Health, Malaysia Vol 16 • 2020

The table below summarises some of the above-mentioned studies related to COVID-19 conducted by ICR or its Clinical
Research Centre (CRC) Network, with relevant collaborators.

Clinical Trials

Institute/Hospital
No. Study Title and Principal Study Background and Progress (As of
27/7/2020)
Investigator (PI)

1 An international randomised trial of Hospital Pulau Provide reliable estimates on any effects of
additional treatments for COVID-19 Pinang & eight other Remdesivir, Hydroxychloroquine, Lopinavir
in hospitalised patients who are all MOH hospitals with Ritonavir and Lopinavir with Ritonavir
receiving the local standard of care. and Interferon in hospital mortality of severe
(WHO Solidarity Trial) PI: Dr Chow Ting Soo COVID-19. Collaboration study with WHO.

(NMRR-20-686-54503) Progress:
Recruitment started 21/4/2020.

2 An open-label, randomised, adaptive Institute for Clinical To compare the efficacy of Methylprednisolone
cross-over interventional study to Research and CRC versus Tocilizumab in improving clinical
evaluate the efficacy and safety of Networks (Hospital outcomes and reducing the need for ventilator
Tocilizumab versus corticosteroid in Sungai Buloh, support in COVID-19 patients with moderate
hospitalised COVID-19 patients with Hospital Kuala COVID-19 disease at risk for complications of
high risk of progression. Lumpur, Hospital cytokine storm. Collaboration between ICR,
Tuanku Jaafar) Hospital Sungai Buloh, Hospital Kuala Lumpur,
(NMRR-20-735-54656) Hospital Tuanku Ja’afar and University Malaya.
PI: Dr. Suresh Kumar
Chidambaram Progress:
Data collection

Clinical Epidemiology

Institute/Hospital
No. Study Title and Principal Study Background and Progress (As of
27/7/2020)
Investigator (PI)

1 COVID-19: Four paediatric cases in Hospital Sungai Brief report of four Paediatric cases of COVID-19
Malaysia. (Short Communication) Buloh infection in Malaysia ranging from 20 months
to 11 years old that contracted virus from China.
PI: Dr See Kwee Collaboration between CRC Hospital Sungai
Ching Buloh, ICR and DDG (P&ST).

Progress:
Published in International Journal of Infectious
Diseases. (doi: 10.1016/j.ijid.2020.03.049)

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