Page 8 - Bulletins No. 4, 1938 sulphanilamide (protosil) in the treatment of malaria

6

Prontosil, as far as this small number of eases goes, cannpt
be considered to be an efficient remedy for P. mahri (C malaria
Case details are given in Appendix A.

THK ACTION ON PRONTOSIL ON GAMETOCYTES.
The number of eases showing "crescents" from day today
during (refitment is given in Table VI and reproduced dia-
ically in Graph />. The number of P. vivar gametocvte
trraunna
•s is shown in Table VII and Graph 6,
carriei

TAIH.E VI.

No. of cn&OB f»!io\vil)i; P. faUipurtiii (jaiiictocytra
on each tiny of trcntinc it.
1
1 2 3 4 5 (i 7
i
Plollluhil 5 8 M 19 24 28 1 31

Quinine !) 11 16 21 17 19 17
i

TAIH,R VII.
No. of cases nlonving P. vims g.uiiotooytes
on encli (lay of treat me it.

• 1 2 1 a 4 -, fi i

Prontosil. 37 34 m 30 2o 18 11

Quinine ... 35 25 i til 1 :>, 2 I.)

It is apparent, that, prontosil is a less efficient P. vim
ganictocidc than quinine and its action on "crest-outs" is als0
unsatisfactory. The detailed daily counts, given in Appendix
H, show lhat the number of crescents in. the blood a I the end
of the course was generally higher in the pronfosil-treated
gamctocyte carriers than in the quinine controls.
Mosquitoes were fed on five prontosil-treated gamctocyte
curriers at the end of the course and in all cases were readily
infected.
ibe heavily infected gametoevte carriers were given a course
of Plasvnoquine treatment before discharge.