Page 4 - Bulletins No. 4, 1938 sulphanilamide (protosil) in the treatment of malaria

2

The sulphanilamide used was Prontosil album (BayerV s
grammes daily were given in two doses. The quinine was given
also twice daily, as a solution at a dosage of 2 grammes per loo
lbs. body weight. Both drugs were given for seven davs

PKONTOSTL IN /'. FALCIPARUM MALARIA.
Prontosil was given to 34 cases controlled by 30 eases
treated with quinine. The response to treatment was judged
by two criteria, disappearance of fever and of asexual parasites
from the peripheral blood. The responses day by day arc shown
in the following tables :

T. \m.K .

.\ "o. of crises showing parasite? onon PUCh
PUC
day of treatment.
I 2 3 4 5 i

Prontosil .. SJ- 31 30 16' 0 a
Quinine ... 30 3:> 25 8 0 (1 (i

T,\ BUS 11.
N o. of cases showing fever on each day
of treatment.

! 2 3 4 5 B (
f
Prontosil... 34 20' 15 5 0 2

Quinine ...
30 14 8 1 0 (J 0

These figures, reduced to percentages are compared dia-
^•ammatieally m graphs 1 and 2. Full case details are given
in Appendix A.
It will be seen that although prontosil abolishes the fever
<<HI parasites m the majority of cases it is not so efficient as
•ljuuiue. I,, five. c a s e s p a r a s i t e g Wfir e s t m p r e B e n t ^ tfae blood
r
fevei ° Tl t h S S e V e t v d a y c o « se and two cases still had
• ibese reqmred quinine treatment before discharge.