Page 130 - Malaysian Journal of Health Promotion, Vol 4 (Supplementary 1) 2022

Malaysian Journal of Health Promotion, Vol 4 (Supplementary 1) 2022
14 MOH-AMM Scientific Meeting 2022 in conjunction with 23 NIH Scientific Conference Abstract Book
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Concordance between both measures was assessed using sensitivity, specificity, and kappa
statistics.
RESULTS:The HSI and FTND both showed a high degree of consistency in measuring the high
level of nicotine addiction. The HSI and FTND had a substantial level of agreement (kappa =
0.72), excellent sensitivity (83.3%) and excellent specificity (89.4%).
DISCUSSION/CONCLUSION: The findings suggest that the HSI can be used instead of the FTND
in clinical-based investigations to screen for high nicotine dependency among daily smokers
in the clinic setting.

ID 162 EFFECT OF CARICA PAPAYA L. LEAF AQUEOUS EXTRACT ON LIVER TOXICITY IN
SPRAGUE DAWLEY RATS

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1
1
Murizal Zainol , Naji Fatimah Hamzah , Shafarin Shamsudin
1 Bioassay Unit , Herbal Medicine Research Centre, Institute for Medical Research National Institutes of Health
(NIH)
2 Laboratory Animal Resource Unit, Special Resource Centre, Institute for Medical Research, Jalan Pahang, Kuala
Lumpur.
INTRODUCTION: The safety aspects of the Carica papaya leaf extract (CPLE) were previously
determined via acute, sub-acute and sub-chronic toxicity. No treatment related changes were
observed except the biochemical parameters such as total protein, HDL- cholesterol,
Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), Alkaline Phosphatase
(ALP) were elevated in a non-dose dependent manner form the sub-acute and sub-chronic
toxicity study. This study was conducted to determine the possible liver toxicity induced by
the CPLE in Sprague Dawley (SD) rats after 28 days of treatment.
METHODS: Forty SD rats (20 males and 20 females) were divided into 4 groups of 10 rats each
with one control group and 3 treatment groups. 0.27, 0.54 and 1,08 g/kg BW of CPLE and
distilled water were administered daily of the respective rat’s group via oral gavage for 28
days prior necropsies. The concentration of AST, ALT, IFN-γ and TNF-α were determined on
day 7, 14 and 28.
RESULTS: No mortality, treatment related changes in the body weight, food and water intake,
liver histopathological, hematological and AST, ALT, IFN-γ and TNF-α in CPLE treated SD rats.
DISCUSSION/CONCLUSION: CPLE did not contribute towards liver toxicity in SD rats treated
for 28 days.

ID 163 SARS-CoV-2 SURFACE CONTAMINATION AND GENOTYPES OBSERVED IN RETURN
GRILLES OF HOSPITALS AND QUARANTINE CENTER DESIGNATED FOR COVID-19 PATIENTS

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1
2
1
Siti Aishah Rashid , Jeyanthi A/P suppiah , Rafiza Binti Shaharudin , Rosnawati Muhamad Robat
1 Environmental Health Research Center, IMR
2 Infectious Disease Research Center, IMR

INTRODUCTION: Environmental detection of SARS-CoV-2 and its variants is crucial in order to
establish preventive measures. This study aims to detect the presence of SARS-CoV-2 and its
variant of concerns (VOC) in the air from swabs of return grilles at facilities treating COVID-19
patients.
METHODS: This was part of a cross-sectional study on bioaerosol and surface sampling
conducted in two designated hospitals and one quarantine center in Klang Valley from
December 2021 to February 2022. A total of 24 samples and 16 control swabs were taken
from return grilles. A quantitative reverse transcription PCR (RT-qPCR) was used to detect

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