Page 55 - IMR Annual Report 2022: Institute for Medical Research

Annual
IMR
Report2022 39
INSTITUTE FOR MEDICAL RESEARCH

Laboratory Diagnostics/ Services

Apart from conducting preclinical in vivo and in vitro toxicity studies, the
Toxicology and Pharmacology unit carries out diagnostic tests for heavy metals.
The majority of samples received are from Ministry of Health (MOH) hospitals and
private laboratories in the Klang Valley. The unit also provides histopathological,
biochemical and haematological analyses for Good Laboratory Practices (GLP)
preclinical toxicology studies.

Tests Performed by the Toxicology & Pharmacology Unit

Year
Test
2021 2022

Heavy Metals:

Urine Copper 1230 1344
Serum Copper 312 353

Blood Lead 9 4

TOTAL 1551 1701

The GLP Section provides GLP-compliant services based on requests from sponsors
for their products to be tested in terms of oral general toxicology in Sprague
Dawley or Wistar rats. Studies conducted follow the Organisation for Economic
Co-operation and Development (OECD) Test Guideline (TG) as follows.

OECD Test Guidelines (TG)

TG Type

420 Acute Oral Toxicity - Fixed Dose Procedure

407 Repeated Dose 28-day Oral Toxicity Study in Rodents

408 Repeated Dose 90-Day Oral Toxicity Study in Rodents

Laboratory services offered by the GLP section for in vivo safety studies are as
follows:

• Animals (rodents) GLP and non- • Gross pathology examination Research Centre (HMRC) Herbal Medicine
GLP laboratories • Weighing of rodent organs
• Animal necropsy rooms • Animal (rodents) functional
• Animal in-life testing –body observation
weight, food intake, water intake, • Histopathology laboratory
general clinical observation • Ophthalmological assessment on
• Biochemistry and hematological animals (rodents)
laboratory