Page 22 - ANTIFUNGAL SUSCEPTIBILITY OF CLINICAL YEAST ISOLATES 2018-2020

6. Candida dubliniensis (C. dubliniensis)

A total of 21 C. dubliniensis were analyzed from various type of clinical

specimens. 13 isolates were mainly from blood (61.9%), followed by tissue (2, 9.5%)
and each one isolate (4.8%) from body fluid and bronchial aspirate as in Table 6.1.

The MIC ranges, MIC50 and MIC90 of seven antifungals are shown in Table 6.2.

This data need be interpreted with caution since there is a limited number of

isolates.

Table 6.1: Distribution of C. dubliniensis isolated based on clinical specimens in
2018-2020.

Specimen Type Number
Blood 13 (61.9%)
Tissue 2 (9.5%)
Bronchial aspirate 1 (4.8%)
Body fluid 1 (4.8%)
Others 4 (19.0%)
Total 21

Table 6.2: MIC50, MIC90 and MIC range values(µg/mL) for C. dubliniensis in 2018-2020.

Antifungals MIC50 MIC90 MIC Range

Amphotericin B 0.094 0.19 0.016 - 0.38

Fluconazole 0.125 0.5 0.064 - 1

Itraconazole 0.094 0.125 0.012 – 0.5

Posaconazole * * *

Voriconazole 0.006 0.012 0.002 – 0.016

Anidulafungin 0.006 0.023 0.002 – 0.12

Caspofungin 0.19 0.38 0.002 - 0.38

Micafungin * * 0.004 - 0.016

5-Fluorocytosine * * *

*The number of isolates tested were very low.

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