Page 15 - ANTIFUNGAL SUSCEPTIBILITY OF CLINICAL YEAST ISOLATES 2018-2020

3. Candida tropicalis (C. tropicalis)

A total of 255 C. tropicalis were analyzed from various type of clinical

specimens. The isolates were mainly from blood (198, 78.0%), followed by tissue
(9, 3.5%) and body fluid (9, 3.5%) (Table 3.1). The MIC ranges, MIC50 and MIC90 of

seven (7) antifungals are shown in Table 3.2.

Table 3.1: Distribution of C. tropicalis isolated based on clinical specimens in 2018-2020.
Specimen Type Number
Blood 198 77.6%
Body fluid 9 3.5%
Tissue 9 3.5%
Pericardial fluid 3 1.2%
Abdominal fluid 2 0.8%
Bronchial aspirate 2 0.8%
Bone 2 0.8%
Abscess 1 0.4%
Bile 1 0.4%
Joint fluid 1 0.4%
Pleural fluid 1 0.4%
Swab 1 0.4%
CSF 1 0.4%
Others 24 9.4%
Total 255

Table 3.2: MIC50, MIC90 and MIC range values (µg/mL) for C. tropicalis in 2018-2020.
Antifungals MIC50 MIC90 MIC Range

Amphotericin B 0.75 1 0.047 - 4

Fluconazole 0.75 256 0.047 - 256

Itraconazole 0.25 1 0.032 - 32

Posaconazole 0.25 1 0.05 - 8

Voriconazole 0.047 1.5 0.005 – 32

Anidulafungin 0.012 0.064 0.001 - 3

Caspofungin 0.032 0.5 0.015 - 32

Micafungin 0.015 0.06 0.004 - 1

5-Fluorocytosine 0.06 0.19 0.006 - 64

15 |