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to a pathological fibroproliferation as what we are seeing in our idiopathic fibrosis
patients. So the reason why they progress is that they lack resorption or removal of
provisional extracellular matrix. Therefore, there will be a residual fibrosis with

pulmonary dysfunction.

In these patients or this cohort, you could actually anticipate because they share

quite similar profiles which are: older age, male and with comorbidities especially
hypertension and diabetes; they are smoking or former smokers. However, patients
who are out of this demographic: they are non-smokers perhaps they are much

younger females and do not have any comorbidities. So they are able to remove all
these extracellular matrix pretty well and the lung will resolve without

fibroproliferation and you could actually translate it to when we do follow-up. We
looked at the radiological resolution on CT scan, there was no evidence of fibrosis
and lung function was back to normal.