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National Institutes of Health





                            disease  2019  (COVID-19)  have  been  reported  to  WHO  (26).  The  WHO  estimates  that  10-
                            20% of people infected with SARS-CoV-2 may develop symptoms classified as long Covid.
                            Globally, the estimated prevalence of long Covid was 37% one month after diagnosis, 25%
                            at two months, 32% at three months, and 49% at four months (27).
                            Long Covid has since gained international recognition in the literature, accompanied by
                            various other descriptors for prolonged or residual COVID-19 symptoms, such as ‘post-acute
                            sequelae  of  COVID-19’,  ‘ongoing  COVID-19’,  ‘chronic  COVID  syndrome’,  ‘long-haul  COVID’,
                            and ‘post-COVID-19’ (28). This widespread acknowledgement underscores the importance
                            of understanding and addressing the long-term consequences of the virus for affected
                            individuals and public health.

                            6.4.1.2  Long Covid Stages
                            Long Covid can be divided into two stages based on the duration of symptoms, as illustrated
                            in Figure 6.4. Post-acute COVID-19 occurs when symptoms persist for over three weeks but
                            less than 12 weeks, whereas chronic COVID-19 occurs when symptoms last longer than 12
                            weeks (29, 30). This distinction is important for understanding the progression and potential
                            treatment strategies for individuals experiencing the lingering effects of the virus.




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                                  Figure 6.4: Stages of long Covid. (Source: Raveendran A. V., et al. (2021))


                            According to several systematic reviews, patients worldwide experienced a wide range
                            of  common  ongoing  symptoms,  sometimes  more  than  60  physical  and  psychological
                            symptoms, including fatigue, malaise, altered smell and taste, breathlessness, and cognitive
                            impairments (31-33). There is also evidence of single or multiple organ impairment in low-
                            risk individuals (31). In Malaysia, almost 20,000 patients who recovered from the coronavirus
                            suffer from long Covid. The five most common symptoms of long Covid are lethargy (78.9%),
                            breathing  difficulty  while  performing  certain  tasks  (52.9%),  coughing  (18.1%),  insomnia
                            (14.5%), and anxiety (10.4%) (34).
                            Based on a cross-sectional study conducted by Moy et al. (2022) from July to September
                            2021, 21% of the 732 survivors who responded to the online survey reported experiencing
                            long  COVID.  Approximately  88%  had  post-COVID-19  symptoms  for  up  to  6  weeks  after
                            diagnosis, 48% for more than six weeks, 21.1% for more than three months (Long Covid), and
                            10% for more than six months. Fatigue, brain fog, depression, anxiety, insomnia, arthralgia,
                            or myalgia were the most commonly reported symptoms of Long Covid (more than three
                            months) (34).











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