Page 49 - IMR ANNUAL REPORT 2021: INSTITUTE FOR MEDICAL RESEARCH
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36 IMR ANNUAL REPORT 2021
Oral Toxicity Test Guidelines (TG) Used by the GLP Section
TG Type
420 Acute Oral Toxicity - Fixed Dose Procedure
407 Repeated Dose 28-day Oral Toxicity Study in Rodents
408 Repeated Dose 90-Day Oral Toxicity Study in Rodents
Laboratory services offered by GLP section for in vivo safety studies are as follows:
HERBAL MEDICINE RESEARCH CENTRE (HMRC) Animals (rodents) GLP and non-GLP laboratories
Animal necropsy rooms
Animal In-Life Testing –Body weight, food intake, water intake, general
clinical observation
Biochemistry and hematological laboratory
Gross pathology examination
Weighing of rodent organs
Animal (rodents) functional observation
Histopathology laboratory
Ophthalmological assessment on animals (rodents)
Preparing rats for clinical observation and weighing for a general
acute toxicity study during monograph research.
