Page 31 - COVID-19-Mortality-review-in-Malaysia-and-updates-on-clinical-management-of-COVID-19

Early and Antiviral combination

This is a study from Hong Kong. They tried with 3 drugs: interferon beta, lopinavir-
ritonavir and ribavirin [6].

The result showed that using the three drugs at <7 days symptoms-onset has the
best outcome. The worst outcome was when lopinavir-ritonavir alone was given at ≥7

days symptom-onset. So, it looks like if you were to use antivirals as a treatment
modality, maybe we need in combination and also have to be given early. So, this
particular study shows that we probably need to give it at < 7 days of disease.

Diagram 13: Hung et al. study showed that combination antiviral therapy and early

treatment has better outcome than single antiviral