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Severe COVID-19 Disease Group: Cytokine Release
Syndrome (CRS) Group
Moving on to the phenotypes of severe disease, as I have mentioned earlier that
everybody has a viral response phase. People who get severe disease, especially one of
the subgroups which I called now as a CRS subgroup where the host inflammatory
response kicks in. It happens somewhere from Day 5 to Day 10 of the disease. The host
inflammatory response kicks in, and they get severe disease. So, the severe disease is
not because the virus is uncontrolled. The severe disease is because of the host
inflammatory response.
Diagram 6: Cytokine Release Syndrome
How do we pick up these patients clinically?
